Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | ESRRG | P62508 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | CA4 | P22748 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20115425 | 1.00 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6720187 | 0.93 | RAB9A (0.87) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL711754 | 0.90 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL711755 | 0.90 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2830919 | 0.90 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1563349 | 0.87 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6634765 | 0.87 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1563347 | 0.87 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13568982 | 0.86 | RAB9A (0.87) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13475702 | 0.85 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118307440-A | Benzoyl hydrazone compound, synthesis method thereof, medicine containing compound and application of compound | 泰州职业技术学院 | 2024-07-09 | — | — | CN | disclosed |
| CN-116396237-A | Green synthesis method of oxadiazole compound | 台州学院 | 2023-07-07 | — | — | CN | disclosed |
| CN-111848441-B | N-substituted benzoyl hydrazone compound and preparation method and application thereof | 山东中新科农生物科技有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-111848441-A | N-substituted benzoyl hydrazone compound and preparation method and application thereof | 朱翠萍 | 2020-10-30 | — | — | CN | disclosed |
| US-10722489-B2 | D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof | PEKING UNIVERSITY (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20200054593-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | UNIV BEIJING (CN) | 2020-02-20 | — | — | US | disclosed |
| US-20190262303-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | UNIV BEIJING (CN) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722489-B2 | D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof | MDH2, MDH1, DLD | RAB9A 4415/4885NPC1 4801/4885SMN1; SMN2 3566/4885 |
| US-20200054593-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | MDH2, MDH1, DLD | RAB9A 4415/4885NPC1 4801/4885SMN1; SMN2 3566/4885 |
| US-20190262303-A1 | D-3-PHOSPHOGLYCERATE DEHYDROGENASE ALLOSTERIC INHIBITOR AND USE THEREOF | MDH2, MDH1, DLD | RAB9A 4415/4885NPC1 4801/4885SMN1; SMN2 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.