Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 8/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3014917 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL129468 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL7761001 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL21253124 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL130779 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL21293895 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL9465223 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL21250203 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL21247774 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 | |
| Bromide SCHEMBL238107 | 1.00 | DNM1 (1.00) | DNM1TSHRALDH1A1THRBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043636-B2 | Method for producing triarylorganoborates | COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) | 2024-07-23 | — | — | US | disclosed |
| US-20240002409-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2024-01-04 | — | — | US | disclosed |
| CN-110325521-A | The method for preparing triaryl organic borate | 科思创德国股份有限公司 | 2019-10-11 | — | — | CN | disclosed |
| EP-3538534-A1 | PROCESS FOR THE PRODUCTION OF TRIARYL ORGANOBORATES | Covestro Deutschland AG (DE) | 2019-09-18 | — | — | EP | disclosed |
| US-20190263838-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2019-08-29 | — | — | US | disclosed |
| CN-110177797-A | Method for producing triaryl organic borate salts | 科思创德国股份有限公司 | 2019-08-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240002409-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | KMO, COASY, CYP3A4 | SIGMAR1 2658/4885DNM1 816/4885TSHR 3184/4885 |
| US-12043636-B2 | Method for producing triarylorganoborates | KMO, COASY, CYP3A4 | SIGMAR1 2658/4885DNM1 816/4885TSHR 3184/4885 |
| US-20190263838-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | CYP3A4, CYP3A43, CYP4B1 | SIGMAR1 2312/4885DNM1 609/4885TSHR 3341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.