SCHEMBL21295558

SCHEMBL21295558

COc1cc(Oc2ccccc2)c(C)cc1N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
ALDH1A1 P00352 7/20 0.46
L3MBTL1 Q9Y468 3/20 0.46
MAPK1 P28482 1/20 0.46
HTT P42858 1/20 0.46
TTR P02766 3/20 0.44
GAA P10253 2/20 0.44
TDP1 Q9NUW8 2/20 0.42
ADRA2B P18089 1/20 0.42
PTGS1 P23219 1/20 0.42
LTA4H P09960 1/20 0.42
MAPT P10636 2/20 0.42
IDO1 P14902 1/20 0.42
MEN1 O00255 1/20 0.42
THRB P10828 1/20 0.42
KMT2A Q03164 1/20 0.42
EP300 Q09472 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3317596 0.84 CYP3A4 (0.49) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL20521390 0.79 TTR (0.47) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL20262023 0.79 CYP1A2 (0.45) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL1706988 0.79 GAA (0.58) CYP3A4ALDH1A1L3MBTL1MAPK1GAA
SCHEMBL11692589 0.78 TTR (0.53) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL8030933 0.77 CYP1A2 (0.62) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL21305477 0.77 MEN1 (0.43) ALDH1A1L3MBTL1MAPK1HTTTTR
SCHEMBL17466061 0.76 CYP1A2 (0.49) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL21305554 0.76 TTR (0.44) ALDH1A1L3MBTL1MAPK1HTTTTR
SCHEMBL5328536 0.76 AR (0.44) CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2025-07-03 US disclosed
CN-111819172-B Triazine derivatives for the treatment of neurotrophin related diseases 阿泽克制药公司 2024-02-06 CN disclosed
EP-3759088-B1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2023-01-25 EP disclosed
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2022-09-29 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
EP-3759088-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS Alzecure Pharma AB (SE) 2021-01-06 EP disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
CN-111819172-A Triazine derivatives for the treatment of neurotrophin-related disorders 阿泽克制药公司 2020-10-23 CN disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF CYP3A4 4531/4885CYP1A2 2565/4885CYP2C9 4852/4885
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF CYP3A4 4531/4885CYP1A2 2565/4885CYP2C9 4852/4885
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins NTRK2, BDNF, NGF CYP3A4 4426/4885CYP1A2 2171/4885CYP2C9 4815/4885
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF CYP3A4 4426/4885CYP1A2 2171/4885CYP2C9 4815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.