Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13222434 | 0.82 | CA1 (0.56) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL212851 | 0.80 | KDM4E (0.61) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL1424931 | 0.79 | KDM4E (0.75) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL174140 | 0.79 | RAB9A (0.65) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL27768804 | 0.78 | KDM4E (0.58) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL28148469 | 0.77 | HPGDS (0.47) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL173422 | 0.75 | KDM4E (0.67) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL174170 | 0.75 | MEN1 (1.00) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL11008102 | 0.74 | ALDH1A1 (0.53) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9728291 | 0.74 | CYP2A6 (0.42) | RAB9ANPC1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |