Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584380 | 0.83 | TAAR1 (0.52) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 | |
| SCHEMBL9584084 | 0.77 | SLC6A2 (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 | |
| SCHEMBL23723015 | 0.77 | SMN1; SMN2 (0.60) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 | |
| SCHEMBL2030784 | 0.77 | SMN1; SMN2 (0.60) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 | |
| SCHEMBL2033607 | 0.77 | SMN1; SMN2 (0.60) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 | |
| SCHEMBL19011137 | 0.74 | HIF1A (0.57) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 | |
| SCHEMBL5928018 | 0.74 | SLC6A2 (0.48) | HIF1ASMN1; SMN2SLC6A2TAAR1ATM | |
| SCHEMBL11265744 | 0.73 | HIF1A (0.60) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 | |
| SCHEMBL20993736 | 0.73 | SLC6A2 (0.55) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP2C19 | |
| SCHEMBL6438143 | 0.73 | HIF1A (0.55) | HIF1ASMN1; SMN2SLC6A2TAAR1ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | MERCK CANADA INC. (CA) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | CTSL, CTSS, CTSZ | HIF1A 1651/4885SMN1; SMN2 4478/4885SLC6A2 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.