Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LPL | P06858 | 5/20 | 0.50 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14852301 | 0.95 | KDM4E (0.59) | KDM4EGAALPLLIPGKCNH2 | |
| SCHEMBL14852465 | 0.92 | DRD2 (0.54) | KDM4EGAALPLLIPGDRD2 | |
| SCHEMBL586677 | 0.86 | GAA (0.53) | KDM4EGAALPLLIPGSIGMAR1 | |
| SCHEMBL19297520 | 0.86 | HSD17B10 (0.44) | KDM4EGAALPLLIPGDRD2 | |
| SCHEMBL586151 | 0.85 | LPL (0.41) | KDM4EGAALPLLIPGDRD2 | |
| SCHEMBL30123801 | 0.85 | DRD2 (0.54) | LPLLIPGDRD2SIGMAR1DRD3 | |
| SCHEMBL15565882 | 0.84 | LPL (0.41) | KDM4EGAALPLLIPGDRD2 | |
| SCHEMBL19211745 | 0.84 | LPL (0.57) | GAALPLLIPGSIGMAR1PLA2G2A | |
| SCHEMBL24504183 | 0.82 | DRD2 (0.47) | KDM4EGAALPLLIPGDRD2 | |
| SCHEMBL19465603 | 0.82 | LPL (0.43) | KDM4EGAALPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3755698-A1 | DEGRADERS OF EGFR AND METHODS OF USE THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2020-12-30 | — | — | EP | disclosed |
| WO-2019164932-A1 | DEGRADERS OF EGFR AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-29 | — | — | WO | disclosed |