SCHEMBL586677

SCHEMBL586677

CCN1CCN(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.53
RAD52 P43351 3/20 0.53
MAPT P10636 2/20 0.53
KDM4E B2RXH2 1/20 0.53
GFER P55789 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CHRNA7 P36544 1/20 0.51
LPL P06858 9/20 0.47
LIPG Q9Y5X9 9/20 0.47
KMT2A Q03164 1/20 0.40
SIGMAR1 Q99720 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
F11 P03951 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19491333 0.90 GAA (0.47) GAARAD52MAPTKDM4EGFER
SCHEMBL14852465 0.88 DRD2 (0.54) GAARAD52MAPTKDM4EGFER
SCHEMBL19465603 0.87 LPL (0.43) GAARAD52MAPTKDM4EGFER
SCHEMBL21296522 0.86 KDM4E (0.51) GAAKDM4ELPLLIPGSIGMAR1
SCHEMBL24506432 0.84 KDM4E (0.41) GAARAD52MAPTKDM4EGFER
SCHEMBL29088143 0.84 LPL (0.41) GAARAD52MAPTKDM4EGFER
SCHEMBL586151 0.84 LPL (0.41) GAAMAPTKDM4ELPLLIPG
SCHEMBL14852301 0.84 KDM4E (0.59) GAAKDM4ELPLLIPGLMNA
SCHEMBL15168853 0.83 LPL (0.41) GAARAD52MAPTKDM4EGFER
SCHEMBL17289947 0.83 LPL (0.44) MAPTKDM4EGFERLPLLIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12595265-B2 Inhibitors of activin receptor-like kinase BLUEPRINT MEDICINES CORPORATION (US) 2026-04-07 US disclosed
US-12534463-B2 Substituted tricyclic compounds as FGFR inhibitors INCYTE CORPORATION (US) 2026-01-27 US disclosed
US-12516059-B2 Pyrazolopyridine compounds and uses thereof INCYTE CORPORATION (US) 2026-01-06 US disclosed
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2025-02-20 US disclosed
US-12209091-B2 Isoindolinone derivatives as selective allosteric inhibitors of Egfr mutant cancers HOFFMANN-LA ROCHE INC. (US) 2025-01-28 US disclosed
US-20240425479-A1 HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2024-12-26 US disclosed
US-20240383889-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2024-11-21 US disclosed
US-20240343704-A1 HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2024-10-17 US disclosed
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2024-09-10 US disclosed
US-20240246974-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS INCYTE CORPORATION 2024-07-25 US disclosed
US-8481525-B2 Kinase inhibitors and method of treating cancer with same UNIVERSITY OF HEALTH NETWORK (CA) 2013-07-09 US disclosed
WO-2013051672-A1 MEDICINAL AGENT COMPRISING THIAZOLIDINE DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT 株式会社ヤクルト本社 (JP) 2013-04-11 WO disclosed
US-20120264800-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER UNIVERSITY HEALTH NETWORKS (CA) 2012-10-18 US disclosed
US-8263596-B2 Kinase inhibitors and method of treating cancer UNIVERSITY HEALTH NETWORK (CA) 2012-09-11 US disclosed
US-20120149686-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME UNIVERSITY HEALTH NETWORKS (CA) 2012-06-14 US disclosed
EP-2417127-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME University Health Network (CA) 2012-02-15 EP disclosed
US-20110263598-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER UNIVERSITY HEALTH NETWORKS (CA) 2011-10-27 US disclosed
WO-2010115279-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME UNIVERSITY HEALTH NETWORK (CA) 2010-10-14 WO disclosed
US-20060004051-A1 Compounds DODIC NERINA 2006-01-05 US disclosed
US-20050245520-A1 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors DODIC NERINA 2005-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050245520-A1 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors SMAD2, SMAD3, ALK GAA 1784/4885RAD52 3885/4885MAPT 1496/4885
US-20240383889-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF PDXK, PCK1, PGK1 GAA 762/4885RAD52 3435/4885MAPT 4343/4885
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 GAA 1045/4885RAD52 4028/4885MAPT 4204/4885
US-12534463-B2 Substituted tricyclic compounds as FGFR inhibitors FGFR3, FGFR1, FGFR4 GAA 2000/4885RAD52 1526/4885MAPT 2782/4885
US-20120264800-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER MAP3K6, MAP3K5, MAP3K19 GAA 1351/4885RAD52 3638/4885MAPT 2002/4885
US-12209091-B2 Isoindolinone derivatives as selective allosteric inhibitors of Egfr mutant cancers EGFR, ERBB2, ERBB3 GAA 3754/4885RAD52 2962/4885MAPT 2305/4885
US-20120149686-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME MAP3K5, MAP3K6, MAP3K1 GAA 1213/4885RAD52 3486/4885MAPT 1467/4885
US-20240246974-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS FGFR3, FGFR1, FGFR2 GAA 205/4885RAD52 3897/4885MAPT 3136/4885
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 GAA 1045/4885RAD52 4028/4885MAPT 4204/4885
US-20110263598-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER MAP3K6, MAP3K5, MAP3K19 GAA 1351/4885RAD52 3638/4885MAPT 2002/4885
US-12595265-B2 Inhibitors of activin receptor-like kinase ACVR1, ACVRL1, ACVR2A GAA 3452/4885RAD52 3392/4885MAPT 4748/4885
US-20060004051-A1 Compounds SMAD3, SMAD2, TGFBR1 GAA 2499/4885RAD52 3874/4885MAPT 697/4885
US-20240343704-A1 HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) CMPK1, WNK1, AAK1 GAA 3039/4885RAD52 4353/4885MAPT 3643/4885
US-20240425479-A1 HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) DCK, CMPK1, WNK1 GAA 2284/4885RAD52 3793/4885MAPT 4500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.