Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 6/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296522 | 0.84 | KDM4E (0.51) | LPLLIPGKDM4EGAADRD2 | |
| SCHEMBL14852301 | 0.82 | KDM4E (0.59) | LPLLIPGKDM4EGAAPLA2G2A | |
| SCHEMBL14852465 | 0.81 | DRD2 (0.54) | LPLLIPGKDM4EGAADRD2 | |
| SCHEMBL15465594 | 0.81 | MAPT (0.36) | LPLLIPGDRD2SIGMAR1MAPT | |
| SCHEMBL19297520 | 0.78 | HSD17B10 (0.44) | LPLLIPGKDM4EGAADRD2 | |
| SCHEMBL586677 | 0.76 | GAA (0.53) | LPLLIPGKDM4EGAASIGMAR1 | |
| SCHEMBL586151 | 0.75 | LPL (0.41) | LPLLIPGKDM4EGAADRD2 | |
| SCHEMBL19583 | 0.75 | ALDH1A1 (0.49) | LPLLIPGKDM4EGAAMAPT | |
| SCHEMBL29429852 | 0.74 | MAPT (0.43) | LPLLIPGMAPTHSD17B10THRA | |
| SCHEMBL10267432 | 0.73 | KMT2A (0.46) | KDM4EGAADRD2MAPTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014026125-A1 | PYRAZINE DERIVATIVES AS FGFR INHIBITORS | INCYTE CORPORATION (US) | 2014-02-13 | — | — | WO | disclosed |