SCHEMBL21298040

SCHEMBL21298040

N#Cc1cc2c(c(C#N)c1C#N)c1cc3ccccc3cc1c1nc3ccccc3n21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.45
ALDH1A1 P00352 7/20 0.45
GAA P10253 4/20 0.45
NPSR1 Q6W5P4 4/20 0.45
MAPT P10636 4/20 0.45
POLB P06746 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
GLA P06280 1/20 0.45
XBP1 P17861 1/20 0.45
KLK7 P49862 1/20 0.44
LMNA P02545 3/20 0.42
RXFP1 Q9HBX9 2/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
KMT2A Q03164 4/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
MAPK1 P28482 2/20 0.41
HPGD P15428 3/20 0.40
MEN1 O00255 2/20 0.40
AURKA O14965 1/20 0.40
PIM1 P11309 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21298222 0.86 KDM4E (0.44) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL21297987 0.85 KDM4E (0.43) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL21297775 0.83 KDM4E (0.45) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL21298044 0.82 KDM4E (0.47) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL21298234 0.82 KDM4E (0.44) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL21790959 0.82 KDM4E (0.33) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL21298149 0.80 MAPK1 (0.36) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL21298038 0.78 KDM4E (0.47) KDM4EALDH1A1GAANPSR1MAPT
SCHEMBL19959757 0.72 KDM4E (0.54) KDM4EALDH1A1GAAMAPTPOLB
SCHEMBL19959759 0.72 KDM4E (0.50) KDM4EALDH1A1GAANPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2021-01-28 US disclosed
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-12-01 US disclosed
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2020-03-05 US disclosed
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885ALDH1A1 2839/4885GAA 1307/4885
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885ALDH1A1 2839/4885GAA 1307/4885
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885ALDH1A1 2839/4885GAA 1307/4885
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials KCNK4, TRPC4, TBRG4 KDM4E 731/4885ALDH1A1 566/4885GAA 2179/4885
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials NT5C, HTR3D, IK KDM4E 2046/4885ALDH1A1 326/4885GAA 2010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.