SCHEMBL21311164

SCHEMBL21311164

Nc1ncnc2c1ncn2C1OC(CSCn2cnc3c(NCc4ccco4)ncnc32)C(O)C1O

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ADORA3 P0DMS8 4/20 0.70
▸ TP53 P04637 2/20 0.70
▸ PAX8 Q06710 2/20 0.70
▸ SMN1; SMN2 Q16637 1/20 0.70
▸ SLC29A1 Q99808 1/20 0.70
▸ MITF O75030 1/20 0.70
▸ LMNA P02545 1/20 0.70
▸ DOT1L Q8TEK3 4/20 0.67
▸ DNMT3B Q9UBC3 3/20 0.59
▸ DNMT1 P26358 2/20 0.59
▸ PNMT P11086 1/20 0.59
▸ PRMT7 Q9NVM4 1/20 0.57
▸ NADK O95544 1/20 0.56
▸ AHCY P23526 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20097018 0.88 ADORA3 (0.70) ADORA3TP53PAX8SMN1; SMN2SLC29A1
SCHEMBL20096994 0.84 DOT1L (0.80) DOT1LDNMT3BDNMT1PNMTPRMT7
SCHEMBL6907808 0.83 DOT1L (0.69) DOT1LDNMT3BDNMT1PNMTPRMT7
Kinetin Riboside SCHEMBL19583061 0.83 ADORA3 (1.00) ADORA3TP53PAX8SMN1; SMN2SLC29A1
Kinetin Riboside SCHEMBL14713468 0.83 ADORA3 (1.00) ADORA3TP53PAX8SMN1; SMN2SLC29A1
Kinetin Riboside SCHEMBL3190252 0.83 ADORA3 (1.00) ADORA3TP53PAX8SMN1; SMN2SLC29A1
Kinetin Riboside SCHEMBL14713232 0.83 ADORA3 (1.00) ADORA3TP53PAX8SMN1; SMN2SLC29A1
Kinetin Riboside SCHEMBL3190271 0.83 ADORA3 (1.00) ADORA3TP53PAX8SMN1; SMN2SLC29A1
Kinetin Riboside SCHEMBL217034 0.83 ADORA3 (1.00) ADORA3TP53PAX8SMN1; SMN2SLC29A1
Kinetin Riboside SCHEMBL3339041 0.83 ADORA3 (1.00) ADORA3TP53PAX8SMN1; SMN2SLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190262371-A1 METHODS AND COMPOSITION FOR THE TREATMENT OF RNA VIRAL INFECTIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2019-08-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190262371-A1 METHODS AND COMPOSITION FOR THE TREATMENT OF RNA VIRAL INFECTIONS POLRMT, EIF2AK2, NSUN3 ADORA3 2754/4885TP53 583/4885PAX8 2873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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