Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | GCG | P01275 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212590 | 0.96 | CTSK (0.36) | CTSKGCGNOTUMABL1ALDH1A1 | |
| SCHEMBL212341 | 0.92 | CTSK (0.37) | CTSKGCGNOTUMABL1ALDH1A1 | |
| SCHEMBL212116 | 0.89 | CTSK (0.36) | CTSKNOTUMABL1ALDH1A1KDM4E | |
| SCHEMBL210644 | 0.88 | NOTUM (0.36) | CTSKNOTUMABL1ALDH1A1KDM4E | |
| SCHEMBL213116 | 0.87 | CCKBR (0.37) | CTSKNOTUMALDH1A1PTGER1DYRK1A | |
| SCHEMBL214202 | 0.86 | CTSK (0.36) | CTSKGCGNOTUMABL1ALDH1A1 | |
| SCHEMBL210223 | 0.86 | CTSK (0.34) | CTSKGCGNOTUMABL1ALDH1A1 | |
| SCHEMBL211462 | 0.86 | CTSK (0.36) | CTSKNOTUMABL1ALDH1A1KDM4E | |
| SCHEMBL4353508 | 0.86 | CTSK (0.37) | CTSKNOTUMABL1ALDH1A1MAPT | |
| SCHEMBL213670 | 0.85 | CTSK (0.35) | CTSKGCGNOTUMABL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |