Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128455 | 0.88 | CSF1R (0.48) | CSF1RLOXL2NR1H4RAB9AKDM4E | |
| SCHEMBL2129436 | 0.86 | CSF1R (0.43) | CSF1RLOXL2NR1H4RAB9AKDM4E | |
| SCHEMBL2129386 | 0.82 | LMNA (0.44) | NR1H4SMN1; SMN2GAAKMT2AMAPT | |
| SCHEMBL2131027 | 0.74 | CSF1R (0.46) | CSF1RLOXL2NR1H4RAB9AKDM4E | |
| SCHEMBL16420939 | 0.73 | KDM4E (0.54) | LOXL2TP53RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL2128489 | 0.71 | MAPT (0.48) | CSF1RLOXL2NR1H4RAB9AKDM4E | |
| SCHEMBL8349147 | 0.71 | LOXL2 (0.46) | LOXL2TP53RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL5067508 | 0.69 | LOXL2 (0.61) | LOXL2RAB9AKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL17512626 | 0.68 | NQO2 (0.44) | KDM4ESMN1; SMN2GAAMAPTMAPK1 | |
| SCHEMBL1474021 | 0.68 | ALDH1A1 (0.65) | LOXL2RAB9AKDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084147-B1 | HETEROCYCLIC FXR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2012-04-25 | — | — | EP | disclosed |
| US-20100184809-A1 | Heterocyclic FXR Binding Compounds | PHENEX PHARMACEUTICALS AG (DE) | 2010-07-22 | — | — | US | disclosed |
| CN-101511813-A | Heterocyclic FXR binding compounds | PHENEX PHARMACEUTICALS AG (DE) | 2009-08-19 | — | — | CN | disclosed |
| EP-2084147-A1 | HETEROCYCLIC FXR BINDING COMPOUNDS | Phenex Pharmaceuticals AG (DE) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008025540-A1 | HETEROCYCLIC FXR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184809-A1 | Heterocyclic FXR Binding Compounds | NR1H4, NR1H2, NR1H3 | CSF1R 1020/4885LOXL2 4196/4885NR1H4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.