Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063561 | 0.75 | CA1 (0.56) | LOXL2ALDH1A1NPC1HPGDYTHDC1 | |
| SCHEMBL5067508 | 0.75 | LOXL2 (0.61) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL8781971 | 0.74 | LOXL2 (0.59) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL3607026 | 0.74 | HDAC3 (0.58) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL7471752 | 0.73 | SMN1; SMN2 (0.56) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL5652892 | 0.72 | SMN1; SMN2 (0.55) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL5642409 | 0.72 | LOXL2 (0.58) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL5507533 | 0.72 | LOXL2 (0.61) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL16420939 | 0.71 | KDM4E (0.54) | LOXL2ALDH1A1SMN1; SMN2GAANPC1 | |
| SCHEMBL32687987 | 0.71 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2NPC1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |