Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.30 |
| ▸ | LSS | P48449 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21318956 | 0.68 | RAB9A (0.41) | RAB9AALDH1A1HTTLMNAKDM4E | |
| SCHEMBL19945798 | 0.65 | KCNQ3 (0.32) | ALDH1A1LMNAKDM4E | |
| SCHEMBL774775 | 0.62 | — | — | |
| SCHEMBL7093887 | 0.60 | HSP90AB1 (0.45) | ALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL23019016 | 0.60 | MAP4K4 (0.35) | RAB9AALDH1A1HTTLMNAKDM4E | |
| SCHEMBL5534484 | 0.59 | ALDH1A1 (0.50) | RAB9AALDH1A1HTTNPC1KDM4E | |
| SCHEMBL32688122 | 0.58 | FABP4 (0.46) | RAB9AFABP4MAT2AALDH1A1HTT | |
| SCHEMBL1268322 | 0.58 | ALDH1A1 (0.46) | RAB9AFABP4ALDH1A1HTTNPC1 | |
| SCHEMBL29950652 | 0.58 | RAB9A (1.00) | RAB9AMAT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL31082905 | 0.57 | ALDH1A1 (0.51) | RAB9AALDH1A1HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294740-B1 | NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |