Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213605 | 0.86 | KDM4E (0.46) | NOTUMWNT3ACHEK1ALDH1A1KDM4E | |
| SCHEMBL213835 | 0.85 | KDM4E (0.47) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL212870 | 0.84 | NOTUM (0.46) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL213202 | 0.84 | NOTUM (0.46) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL2837602 | 0.84 | NOTUM (0.46) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL214063 | 0.84 | NOTUM (0.47) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL215046 | 0.84 | ALDH1A1 (0.48) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL213578 | 0.81 | NOTUM (0.44) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL22550360 | 0.79 | CTSK (0.50) | NOTUMCTSKMTORWNT3ACHEK1 | |
| SCHEMBL22793399 | 0.78 | NOTUM (0.52) | NOTUMCTSKMTORWNT3ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |