Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 10/20 | 0.42 |
| ▸ | VCP | P55072 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GALR2 | O43603 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2132119 | 1.00 | PRMT1 (0.43) | PRMT1FBP1VCPLMNAMAPT | |
| SCHEMBL2131813 | 0.79 | PDE4B (0.39) | LMNAALDH1A1HTTMITFNPSR1 | |
| SCHEMBL30971780 | 0.79 | PDE4B (0.39) | LMNAALDH1A1HTTMITFNPSR1 | |
| SCHEMBL14920924 | 0.78 | FBP1 (0.45) | PRMT1FBP1VCPLMNAMAPT | |
| SCHEMBL14920926 | 0.78 | FBP1 (0.45) | PRMT1FBP1VCPLMNAMAPT | |
| SCHEMBL19172446 | 0.77 | MAPT (0.46) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL2129111 | 0.77 | ALDH1A1 (0.42) | PRMT1FBP1VCPLMNAMAPT | |
| SCHEMBL2129117 | 0.77 | ALDH1A1 (0.42) | PRMT1FBP1VCPLMNAMAPT | |
| SCHEMBL29628340 | 0.75 | NT5E (0.35) | LMNAMAPTALDH1A1HTTMITF | |
| SCHEMBL2132400 | 0.75 | PRMT1 (0.42) | PRMT1FBP1VCPLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379535-B1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2016-06-15 | — | — | EP | disclosed |
| US-8785445-B2 | 7-phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120101103-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2012-04-26 | — | — | US | disclosed |
| EP-2379535-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | Array Biopharma Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010075200-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101103-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | PTGDR2, PTGDR, HRH2 | PRMT1 1086/4885FBP1 4368/4885VCP 4716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.