SCHEMBL21327768

SCHEMBL21327768

O=[N+]([O-])c1nccn1CC(CO)(CO)CCl

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.48
THRB P10828 1/20 0.48
CYP2C19 P33261 1/20 0.48
KMT2A Q03164 2/20 0.44
TYMP P19971 3/20 0.43
CA12 O43570 5/20 0.43
CA1 P00915 5/20 0.43
CA2 P00918 5/20 0.43
CA9 Q16790 5/20 0.43
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
OPRK1 P41145 1/20 0.41
NOS1 P29475 1/20 0.33
CCR10 P46092 2/20 0.32
MEN1 O00255 1/20 0.32
HTT P42858 2/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28639392 0.91 LMNA (0.52) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL21327770 0.91 LMNA (0.52) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL16284421 0.86 LMNA (0.48) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL14822352 0.86 LMNA (0.48) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL26657822 0.86 CYP2C19 (0.48) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL14822584 0.86 LMNA (0.48) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL9441389 0.79 LMNA (0.50) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL18823119 0.78 LMNA (0.49) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL8530813 0.76 LMNA (0.59) LMNATHRBCYP2C19KMT2ATYMP
SCHEMBL15597325 0.76 TYMP (0.56) LMNATHRBCYP2C19KMT2ATYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3536686-B1 METHOD FOR PRODUCING A RADIOPHARMACEUTICAL COMPOSITION NIHON MEDIPHYSICS CO LTD (JP) 2021-11-24 EP disclosed
EP-3536686-B1 METHOD FOR PRODUCING A RADIOPHARMACEUTICAL COMPOSITION NIHON MEDIPHYSICS CO LTD (JP) 2021-11-24 EP disclosed
US-10703726-B2 Method for producing radiopharmaceutical composition NIHON MEDI-PHYSICS CO., LTD. (JP) 2020-07-07 US disclosed
US-20190276411-A1 Method for Producing Radiopharmaceutical Composition NIHON MEDI-PHYSICS CO., LTD. (JP) 2019-09-12 US disclosed
EP-3536686-A1 METHOD FOR PRODUCING A RADIOPHARMACEUTICAL COMPOSITION NIHON MEDI-PHYSICS CO., LTD (JP) 2019-09-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10703726-B2 Method for producing radiopharmaceutical composition NAA15, TMEM14C, FLNA LMNA 2138/4885THRB 438/4885CYP2C19 226/4885
US-20190276411-A1 Method for Producing Radiopharmaceutical Composition NAA15, TMEM14C, FLNA LMNA 2138/4885THRB 438/4885CYP2C19 226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.