Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.75 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21328330 | 0.96 | TTR (0.71) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL21328363 | 0.92 | TTR (0.65) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL30074670 | 0.91 | CA2 (0.68) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL185845 | 0.91 | CA2 (0.68) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL13236279 | 0.87 | TTR (1.00) | TTRCA2ALDH1A1MEN1KMT2A | |
| SCHEMBL2799091 | 0.86 | TTR (1.00) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL21328338 | 0.84 | TTR (0.79) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL9705942 | 0.82 | TTR (0.58) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL11333719 | 0.82 | CALM1 (0.61) | TTRCA2ATMKDM4EALDH1A1 | |
| SCHEMBL21328355 | 0.82 | TTR (0.57) | TTRCA2ATMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190275027-A1 | Bis-Benzyl-Tetrahydroisoquinoline Derivatives As Therapeutics For Filovirus | SOUTHWEST RESEARCH INSTITUTE | 2019-09-12 | — | — | US | disclosed |
| US-20190275027-A1 | Bis-Benzyl-Tetrahydroisoquinoline Derivatives As Therapeutics For Filovirus | SOUTHWEST RESEARCH INSTITUTE | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190275027-A1 | Bis-Benzyl-Tetrahydroisoquinoline Derivatives As Therapeutics For Filovirus | TREH, TTN, TSN | TTR 483/4885CA2 3580/4885ATM 3917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.