Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 8/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.35 |
| ▸ | HTR3B | O95264 | 3/20 | 0.35 |
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 5/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31546719 | 0.85 | IDH1 (0.38) | IDH1TSHRCYP3A4HTR3EHTR3B | |
| SCHEMBL17449295 | 0.81 | MEN1 (0.42) | IDH1TSHRCYP3A4HTR3EHTR3B | |
| SCHEMBL31108761 | 0.81 | MEN1 (0.42) | IDH1TSHRCYP3A4HTR3EHTR3B | |
| SCHEMBL31546858 | 0.81 | CNR2 (0.45) | IDH1TSHRCYP3A4HTR3EHTR3B | |
| SCHEMBL4914453 | 0.78 | TSHR (0.42) | IDH1TSHRCYP3A4HTR3EHTR3B | |
| SCHEMBL17449293 | 0.78 | IDH1 (0.41) | IDH1TSHRCYP3A4HTR3EHTR3B | |
| SCHEMBL13991766 | 0.78 | TSHR (0.42) | IDH1TSHRCYP3A4HTR3EHTR3B | |
| SCHEMBL31543163 | 0.76 | KDM1A (0.30) | — | |
| SCHEMBL31106145 | 0.76 | HTR1A (0.40) | IDH1 | |
| SCHEMBL23089447 | 0.76 | CHRNB2 (0.46) | IDH1TSHRCYP3A4HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200255423-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC (US) | 2020-08-13 | — | — | US | disclosed |
| US-20200255423-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC (US) | 2020-08-13 | — | — | US | disclosed |
| WO-2019178079-A9 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC. (US) | 2019-12-12 | — | — | WO | disclosed |
| WO-2019178079-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC. (US) | 2019-09-19 | — | — | WO | disclosed |
| EP-3539966-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | AbbVie Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| EP-3539966-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | AbbVie Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| US-20190276450-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC. | 2019-09-12 | — | — | US | disclosed |
| US-20190276450-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC. | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190276450-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | PTK2B, ABL1, BTK | IDH1 812/4885TSHR 519/4885CYP3A4 1753/4885 |
| US-20200255423-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | PTK2B, ABL1, BTK | IDH1 812/4885TSHR 519/4885CYP3A4 1753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.