Sugi Predict

Sugi Predict / Compounds / SCHEMBL21332974

SCHEMBL21332974

SCHEMBL21332974

Cc1c(C(=O)Cn2cc(C#C[Si](C)(C)C)ccc2=O)cnn1Cc1cccc(C#N)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CREBBP Q92793 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ KMT2A Q03164 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ SDHB P21912 1/20 0.37
▸ IDH1 O75874 1/20 0.37
▸ RXFP1 Q9HBX9 1/20 0.36
▸ ADRA1D P25100 1/20 0.35
▸ S1PR2 O95136 1/20 0.35
▸ PDE1A P54750 1/20 0.35
▸ PDE1C Q14123 1/20 0.35
▸ KLKB1 P03952 2/20 0.35
▸ KLK1 P06870 1/20 0.35
▸ BRD4 O60885 1/20 0.35
▸ DRD4 P21917 1/20 0.35
▸ DRD3 P35462 1/20 0.35
▸ TAS2R8 Q9NYW2 2/20 0.34
▸ POLB P06746 1/20 0.34
▸ MET P08581 1/20 0.34
▸ ALKBH1 Q13686 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30866456 0.89 CREBBP (0.42) CREBBPL3MBTL1KMT2ASMN1; SMN2SDHB
SCHEMBL21333033 0.89 CREBBP (0.42) CREBBPL3MBTL1KMT2ASMN1; SMN2SDHB
SCHEMBL21333078 0.86 CREBBP (0.43) CREBBPL3MBTL1KMT2ASMN1; SMN2SDHB
SCHEMBL30866453 0.86 CREBBP (0.43) CREBBPL3MBTL1KMT2ASMN1; SMN2SDHB
SCHEMBL21332993 0.86 ABHD6 (0.42) KMT2ASMN1; SMN2S1PR2TAS2R8POLB
SCHEMBL21333089 0.83 PTGDR2 (0.39) KMT2ASMN1; SMN2S1PR2POLBSLC2A1
SCHEMBL21332669 0.78 KDM4E (0.43) KMT2ASMN1; SMN2S1PR2BRD4POLB
SCHEMBL21332677 0.77 KDM4E (0.42) KMT2ASMN1; SMN2S1PR2BRD4
SCHEMBL21333082 0.77 KMT2A (0.40) L3MBTL1KMT2ASMN1; SMN2S1PR2TAS2R8
SCHEMBL30866462 0.77 KMT2A (0.40) L3MBTL1KMT2ASMN1; SMN2S1PR2TAS2R8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3762377-B1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF UNIV CORNELL (US) 2025-08-20 — — EP disclosed
US-11964960-B2 Pyridinone- and pyridazinone-based compounds and uses thereof CORNELL UNIVERSITY (US) 2024-04-23 — — US disclosed
EP-3762377-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF Cook, Timothy, H. (US) 2021-01-13 — — EP disclosed
US-20200407339-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE 2020-12-31 — — US disclosed
WO-2019173790-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF HLA TIMOTHY (US) 2019-09-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200407339-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF PTGER1, LOXL1, COL1A1 CREBBP 2747/4885L3MBTL1 1788/4885KMT2A 4385/4885
US-11964960-B2 Pyridinone- and pyridazinone-based compounds and uses thereof PTGER1, LOXL1, COL1A1 CREBBP 2747/4885L3MBTL1 1788/4885KMT2A 4385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.