Sugi Predict

Sugi Predict / Compounds / SCHEMBL21333089

SCHEMBL21333089

SCHEMBL21333089

Cc1c(C(=O)Cn2cc(C#C[Si](C)(C)C)ccc2=O)cnn1Cc1ccc(F)cc1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PTGDR2 Q9Y5Y4 7/20 0.39
▸ S1PR2 O95136 1/20 0.36
▸ TP53 P04637 4/20 0.36
▸ POLB P06746 3/20 0.36
▸ KDM4E B2RXH2 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ MAPT P10636 2/20 0.35
▸ MITF O75030 1/20 0.35
▸ PKM P14618 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ SLC2A1 P11166 1/20 0.35
▸ SLC2A3 P11169 1/20 0.35
▸ SLC2A4 P14672 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21332838 0.88 PTGDR2 (0.41) PTGDR2S1PR2TP53POLBKDM4E
SCHEMBL21332974 0.83 CREBBP (0.41) S1PR2POLBKMT2ASMN1; SMN2SLC2A1
SCHEMBL21332885 0.82 PTGDR2 (0.41) PTGDR2S1PR2TP53POLBKDM4E
SCHEMBL21332993 0.81 ABHD6 (0.42) S1PR2POLBKMT2ALMNASMN1; SMN2
SCHEMBL21332677 0.80 KDM4E (0.42) PTGDR2S1PR2TP53KDM4EKMT2A
SCHEMBL21333313 0.80 PTGDR2 (0.39) PTGDR2S1PR2TP53POLBKDM4E
SCHEMBL21332669 0.78 KDM4E (0.43) PTGDR2S1PR2TP53POLBKDM4E
SCHEMBL21333548 0.78 S1PR2 (0.45) PTGDR2S1PR2TP53KDM4EKMT2A
SCHEMBL21332947 0.73 SMN1; SMN2 (0.47) PTGDR2TP53POLBKDM4EKMT2A
SCHEMBL21333229 0.72 MITF (0.45) PTGDR2TP53POLBKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3762377-B1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF UNIV CORNELL (US) 2025-08-20 — — EP disclosed
US-11964960-B2 Pyridinone- and pyridazinone-based compounds and uses thereof CORNELL UNIVERSITY (US) 2024-04-23 — — US disclosed
EP-3762377-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF Cook, Timothy, H. (US) 2021-01-13 — — EP disclosed
US-20200407339-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE 2020-12-31 — — US disclosed
WO-2019173790-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF HLA TIMOTHY (US) 2019-09-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200407339-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF PTGER1, LOXL1, COL1A1 PTGDR2 103/4885S1PR2 601/4885TP53 2741/4885
US-11964960-B2 Pyridinone- and pyridazinone-based compounds and uses thereof PTGER1, LOXL1, COL1A1 PTGDR2 103/4885S1PR2 601/4885TP53 2741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.