Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.59 |
| ▸ | HPGD | P15428 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4227925 | 0.85 | MAPT (0.48) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21333625 | 0.82 | MAPT (0.66) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL5458275 | 0.78 | PDE4B (0.63) | MAPTALDH1A1HPGDKDM4EPDE4B | |
| SCHEMBL21347821 | 0.77 | MAPT (0.49) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21333744 | 0.76 | RAB9A (0.71) | MAPTALDH1A1KDM4EPDE4BPDE4D | |
| SCHEMBL21346848 | 0.76 | PDE4B (0.68) | MAPTALDH1A1HPGDKDM4EPDE4B | |
| SCHEMBL20254478 | 0.75 | MAPT (0.49) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL1718839 | 0.75 | MAPT (1.00) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21260713 | 0.74 | PDE4B (0.52) | MAPTALDH1A1HPGDHSD17B10PDE4B | |
| SCHEMBL21346852 | 0.74 | PDE4B (0.56) | MAPTALDH1A1HPGDKDM4EPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762383-B1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | US HEALTH (US) | 2023-12-06 | — | — | EP | disclosed |
| US-20210040074-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-02-11 | — | — | US | disclosed |
| US-20210040074-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-02-11 | — | — | US | disclosed |
| EP-3762383-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2021-01-13 | — | — | EP | disclosed |
| WO-2019173437-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040074-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | CHRM1, MTNR1A, CHRNA3 | MAPT 658/4885ALDH1A1 2614/4885HPGD 2034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.