Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | FLT3 | P36888 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | MGAM | O43451 | 4/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.53 |
| ▸ | RORC | P51449 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21346848 | 0.89 | PDE4B (0.68) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL21347432 | 0.85 | RAB9A (0.78) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL21346969 | 0.83 | MAPT (0.79) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL21247126 | 0.82 | RAB9A (0.65) | RAB9AALDH1A1MAPTNPC1FLT3 | |
| SCHEMBL5457779 | 0.81 | RAB9A (1.00) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL5458275 | 0.78 | PDE4B (0.63) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL21346852 | 0.78 | PDE4B (0.56) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL2182372 | 0.77 | TP53 (0.80) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL21247240 | 0.76 | TNF (0.60) | RAB9AALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL21247256 | 0.76 | RAB9A (0.60) | RAB9AALDH1A1MAPTNPC1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210040074-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-02-11 | — | — | US | disclosed |
| EP-3762383-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2021-01-13 | — | — | EP | disclosed |
| WO-2019173437-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-09-12 | — | — | WO | disclosed |
| WO-2019173437-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040074-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | CHRM1, MTNR1A, CHRNA3 | RAB9A 355/4885ALDH1A1 2614/4885KDM4E 4085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.