Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 14/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.45 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069232 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2APPMAPK1 | |
| SCHEMBL4893890 | 0.80 | RAB9A (0.57) | TNIKSMN1; SMN2 | |
| SCHEMBL3070625 | 0.80 | TRPM8 (0.62) | TNIKSMN1; SMN2 | |
| SCHEMBL3488442 | 0.80 | AXL (0.62) | TNIKSMN1; SMN2APP | |
| SCHEMBL27883363 | 0.80 | SMN1; SMN2 (0.56) | TNIKSMN1; SMN2 | |
| SCHEMBL3228033 | 0.80 | MEN1 (0.61) | TNIKSMN1; SMN2MAPK1 | |
| SCHEMBL13514605 | 0.80 | SMN1; SMN2 (0.47) | TNIKSMN1; SMN2MAPK1 | |
| SCHEMBL8808272 | 0.79 | MAP2K4 (0.49) | TNIKSMN1; SMN2MAPK1MAP2K4 | |
| SCHEMBL1773863 | 0.79 | RAB9A (0.61) | TNIKSMN1; SMN2 | |
| SCHEMBL20662085 | 0.78 | XDH (0.46) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019170050-A1 | 2-THIOMETHYLPYRAZOLOPYRIMIDINONE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 云南大学 | 2019-09-12 | — | — | WO | disclosed |