Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pipamperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.94 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.94 |
| ▸ | DRD1 | P21728 | 2/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.94 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.94 |
| ▸ | DRD3 | P35462 | 2/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.94 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.94 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pipamperone SCHEMBL2412 | 0.97 | HTR1A (1.00) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL6621425 | 0.97 | HTR1A (1.00) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL7405 | 0.96 | HTR1A (0.94) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL647930 | 0.96 | HTR1A (0.98) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL364623 | 0.96 | HTR1A (0.98) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL4671026 | 0.96 | HTR1A (0.98) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL14696833 | 0.96 | HTR1A (0.98) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL8764867 | 0.96 | HTR1A (0.98) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL10533161 | 0.96 | HTR1A (0.98) | HTR1AADRA2ADRD1ADRA1AOPRM1 | |
| Pipamperone SCHEMBL538546 | 0.95 | DRD3 (0.92) | HTR1AADRA2ADRD1ADRA1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102617543-A | Synthesis methods for piperonyl ethanol and derivatives thereof | UNIV TIANJIN SCIENCE & TECH | 2012-08-01 | — | — | CN | claimed |
| CN-113264814-B | Process for preparing hydroxytyrosol | 南京斯贝源医药科技有限公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-113264814-A | Process for preparing hydroxytyrosol | 南京斯贝源医药科技有限公司 | 2021-08-17 | — | — | CN | disclosed |
| WO-2019174560-A1 | COMPOSITION FOR PURIFICATION OF BIOFLUIDS | 必康生技（香港）有限公司 | 2019-09-19 | — | — | WO | disclosed |
| CN-102617543-A | Synthesis methods for piperonyl ethanol and derivatives thereof | UNIV TIANJIN SCIENCE & TECH | 2012-08-01 | — | — | CN | disclosed |
| CN-102617543-A | Synthesis methods for piperonyl ethanol and derivatives thereof | UNIV TIANJIN SCIENCE & TECH | 2012-08-01 | — | — | CN | disclosed |
| CN-102617543-A | Synthesis methods for piperonyl ethanol and derivatives thereof | UNIV TIANJIN SCIENCE & TECH | 2012-08-01 | — | — | CN | disclosed |
| CN-86100669-A | The synthetic organic polymers that is used for selective flocculating floatation of titanium and iron ores | — | 1987-08-05 | — | — | CN | disclosed |