Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pipamperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.92 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.52 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.52 |
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.92 |
| ▸ | HTR1A | P08908 | 3/20 | 0.92 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.92 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.92 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.92 |
| ▸ | DRD1 | P21728 | 2/20 | 0.92 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.92 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.92 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pipamperone SCHEMBL7405 | 0.97 | HTR1A (0.94) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL2412 | 0.96 | HTR1A (1.00) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL6621425 | 0.96 | HTR1A (1.00) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL21357035 | 0.95 | HTR1A (0.94) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL364623 | 0.95 | HTR1A (0.98) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL4671026 | 0.95 | HTR1A (0.98) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL647930 | 0.95 | HTR1A (0.98) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL8764867 | 0.95 | HTR1A (0.98) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL14696833 | 0.95 | HTR1A (0.98) | DRD3HTR1AADRA2AADRA1AOPRM1 | |
| Pipamperone SCHEMBL10533161 | 0.95 | HTR1A (0.98) | DRD3HTR1AADRA2AADRA1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413935-A1 | LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS | PharmaNeuroBoost N.V. (BE) | 2012-02-08 | — | — | EP | claimed |
| US-20120010242-A1 | LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS | ALKERSTRAAT 30 A (BE) | 2012-01-12 | — | — | US | claimed |
| WO-2010112529-A1 | LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS | PHARMANEUROBOOST N.V. (BE) | 2010-10-07 | — | — | WO | claimed |
| WO-2012072665-A1 | COMPOSITIONS COMPRISING PIPAMPERONE AND SEROTONIN ANTAGONIST REUPTAKE INHIBITORS | PHARMANEUROBOOST N.V. (BE) | 2012-06-07 | — | — | WO | disclosed |
| EP-2413935-A1 | LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS | PharmaNeuroBoost N.V. (BE) | 2012-02-08 | — | — | EP | disclosed |
| US-20120010242-A1 | LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS | ALKERSTRAAT 30 A (BE) | 2012-01-12 | — | — | US | disclosed |
| WO-2010112529-A1 | LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS | PHARMANEUROBOOST N.V. (BE) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010112530-A1 | PIPAMPERONE AND A SECOND AGENT IN TREATING MOOD AND ANXIETY DISORDERS | PHARMANEUROBOOST N.V. (BE) | 2010-10-07 | — | — | WO | disclosed |
| EP-2236138-A1 | Low dose pipamperone in treating mood and anxiety disorders | PharmaNeuroBoost N.V. (BE) | 2010-10-06 | — | — | EP | disclosed |
| EP-2236157-A1 | Pipamperone and a second agent in treating mood and anxiety disorders | PharmaNeuroBoost N.V. (BE) | 2010-10-06 | — | — | EP | disclosed |