Pipamperone

Pipamperone

SCHEMBL364623

Cl.Cl.NC(=O)C1(N2CCCCC2)CCN(CCCC(=O)c2ccc(F)cc2)CC1

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Pipamperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A known ✓ P08908 3/20 0.98
ADRA2A known ✓ P08913 3/20 0.98
SLC6A4 known ✓ P31645 3/20 0.98
ADRA1A known ✓ P35348 3/20 0.98
OPRM1 known ✓ P35372 3/20 0.98
DRD3 known ✓ P35462 3/20 0.98
SLC6A3 known ✓ Q01959 3/20 0.98
KCNH2 known ✓ Q12809 3/20 0.98
DRD1 known ✓ P21728 2/20 0.98
HRH3 known ✓ Q9Y5N1 1/20 0.98
DRD2 known ✓ P14416 7/20 0.60
CHRM1 known ✓ P11229 2/20 0.54
ADRA2B known ✓ P18089 2/20 0.54
ADRA2C known ✓ P18825 2/20 0.54
CHRM3 known ✓ P20309 2/20 0.54
SLC6A2 known ✓ P23975 2/20 0.54
HTR2A known ✓ P28223 2/20 0.54
HRH1 known ✓ P35367 2/20 0.54
HTR2B known ✓ P41595 2/20 0.54
GHSR known ✓ Q92847 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pipamperone SCHEMBL8764867 1.00 HTR1A (0.98) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL4671026 1.00 HTR1A (0.98) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL2412 0.99 HTR1A (1.00) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL6621425 0.99 HTR1A (1.00) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL647930 0.98 HTR1A (0.98) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL14696833 0.98 HTR1A (0.98) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL10533161 0.98 HTR1A (0.98) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL2552074 0.97 HTR1A (0.96) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL8327319 0.97 HTR1A (0.96) HTR1AADRA2ASLC6A4ADRA1AOPRM1
Pipamperone SCHEMBL21357035 0.96 HTR1A (0.94) HTR1AADRA2ASLC6A4ADRA1AOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240324606-A1 ARTHROPOD CONTROL PRODUCTS FIRMENICH SA (CH) 2024-10-03 US claimed
EP-4380366-A1 ARTHROPOD CONTROL PRODUCTS Firmenich SA (CH) 2024-06-12 EP claimed
WO-2023052456-A1 ARTHROPOD CONTROL PRODUCTS FIRMENICH SA (CH) 2023-04-06 WO claimed
US-20230095618-A1 OIL-IN-WATER EMULSION COMPRISING A SOLID LIPID MATERIAL FIRMENICH SA (CH) 2023-03-30 US claimed
EP-4125778-A1 OIL-IN-WATER EMULSION COMPRISING A SOLID LIPID MATERIAL Firmenich SA (CH) 2023-02-08 EP claimed
WO-2021198198-A1 OIL-IN-WATER EMULSION COMPRISING A SOLID LIPID MATERIAL FIRMENICH SA (CH) 2021-10-07 WO claimed
US-20150099741-A1 DIAGNOSING AND TREATING PATIENTS HAVING PSYCHIATRIC DISORDERS NORTHWESTERN UNIVERSITY (US) 2015-04-09 US claimed
EP-2413935-A1 LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS PharmaNeuroBoost N.V. (BE) 2012-02-08 EP claimed
US-20120010242-A1 LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS ALKERSTRAAT 30 A (BE) 2012-01-12 US claimed
WO-2010112529-A1 LOW DOSE PIPAMPERONE IN TREATING MOOD DISORDERS PHARMANEUROBOOST N.V. (BE) 2010-10-07 WO claimed
EP-1273301-B1 Pharmaceutical preparations based on active ingredients susceptible to illicit administration ALTERGON SA (CH) 2006-09-06 EP claimed
WO-2006023497-A2 INTRANASAL DELIVERY OF ANTIPSYCHOTIC DRUGS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2006-03-02 WO claimed
US-20060039869-A1 Intranasal delivery of antipsychotic drugs UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2006-02-23 US claimed
EP-1273301-A2 Pharmaceutical preparations based on active ingredients susceptible to illicit administration ALTERGON S.A. (CH) 2003-01-08 EP claimed
US-5811547-A Method for inducing crystalline state transition in medicinal substance NIPPON SHINYAJU CO., LTD. (JP) 1998-09-22 US claimed
US-12582606-B2 Tablet and method for producing tablet SUNSHO PHARMACEUTICAL CO., LTD. (JP) 2026-03-24 US disclosed
US-12410474-B2 Methods, kits, and devices for diagnosing, prognosing, and treating psychiatric disorders in a patient NORTHWESTERN UNIVERSITY (US) 2025-09-09 US disclosed
US-5811547-A Method for inducing crystalline state transition in medicinal substance NIPPON SHINYAJU CO., LTD. (JP) 1998-09-22 US disclosed
WO-1998000198-A1 PHARMACEUTICAL ADMINISTRATION FORM MUELLER DIETER (DE) 1998-01-08 WO disclosed
EP-0665009-A1 CRYSTALLINE CONDITION DISLOCATING METHOD NIPPON SHINYAKU COMPANY, LIMITED (JP) 1995-08-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12582606-B2 Tablet and method for producing tablet GRHPR, RCC1, KIT HTR1A 1430/4885ADRA2A 2229/4885SLC6A4 3595/4885
US-20060039869-A1 Intranasal delivery of antipsychotic drugs HTT, SLC6A3, HTR6 HTR1A 19/4885ADRA2A 505/4885SLC6A4 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.