Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25051595 | 0.89 | CHEK1 (0.38) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL19534272 | 0.88 | ALDH1A1 (0.40) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL625633 | 0.87 | CHEK1 (0.38) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL15648710 | 0.87 | TSHR (0.49) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL14919592 | 0.83 | CYP3A4 (0.33) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL13780350 | 0.82 | CYP2D6 (0.46) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL349580 | 0.81 | TSHR (0.46) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL616034 | 0.79 | TSHR (0.38) | TSHRCYP1A2 | |
| SCHEMBL22906067 | 0.78 | CYP2D6 (0.42) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL30708152 | 0.78 | CYP2C19 (0.36) | TSHRCYP3A4CYP2D6ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2022-04-07 | — | — | US | disclosed |
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-02-08 | — | — | US | disclosed |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| EP-3765020-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences B.V. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177997-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | RORA, RORC, RORB | TSHR 193/4885CYP3A4 964/4885CYP2D6 896/4885 |
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | TSHR 193/4885CYP3A4 964/4885CYP2D6 896/4885 |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | TSHR 185/4885CYP3A4 863/4885CYP2D6 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.