Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 3/20 | 0.47 |
| ▸ | FNTB | P49356 | 3/20 | 0.47 |
| ▸ | RORC | P51449 | 4/20 | 0.43 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 8/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 8/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17912637 | 0.77 | RORC (0.56) | FNTAFNTBRORC | |
| SCHEMBL17339178 | 0.73 | FNTA (0.52) | FNTAFNTBBAZ2BBAZ2ADAO | |
| SCHEMBL17339062 | 0.73 | FNTA (0.51) | FNTAFNTBBAZ2BBAZ2ADAO | |
| SCHEMBL17339103 | 0.71 | BAZ2B (0.49) | FNTAFNTBBAZ2BBAZ2ADAO | |
| SCHEMBL17339106 | 0.71 | FNTA (0.60) | FNTAFNTBBAZ2BBAZ2ABRD4 | |
| SCHEMBL17912519 | 0.71 | RORC (0.51) | RORC | |
| SCHEMBL30152797 | 0.70 | KDM4E (0.37) | RORCCNR2BRD4BRD9ALDH1A1 | |
| SCHEMBL17339134 | 0.70 | FNTA (0.48) | FNTAFNTBBAZ2BBAZ2ADAO | |
| SCHEMBL4491096 | 0.68 | CNR2 (0.64) | RORCCNR2 | |
| SCHEMBL16973593 | 0.65 | FNTA (0.41) | FNTAFNTBDAOMCL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765459-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | Shire Human Genetic Therapies, Inc. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019178129-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2019-09-19 | — | — | WO | disclosed |