Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446501 | 0.89 | SNCA (0.36) | ALDH1A1LMNAMAPTGAACYP1A2 | |
| SCHEMBL10596213 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTGAACYP2C19 | |
| SCHEMBL21358833 | 0.84 | CYP1A2 (0.39) | ALDH1A1LMNAMAPTGAACYP1A2 | |
| SCHEMBL16684874 | 0.82 | LMNA (0.43) | ALDH1A1LMNAMAPTCYP2D6L3MBTL1 | |
| SCHEMBL8134017 | 0.82 | TDP1 (0.39) | ALDH1A1LMNAMAPTGAACYP1A2 | |
| SCHEMBL10598218 | 0.82 | SNCA (0.39) | ALDH1A1LMNAMAPTGAACYP2C19 | |
| SCHEMBL10503748 | 0.81 | LMNA (0.38) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10963612 | 0.81 | LMNA (0.38) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10961388 | 0.81 | LMNA (0.38) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10961874 | 0.81 | LMNA (0.38) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178079-A9 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC. (US) | 2019-12-12 | — | — | WO | disclosed |
| WO-2019178079-A1 | INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING | ABBVIE INC. (US) | 2019-09-19 | — | — | WO | disclosed |