Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389258 | 0.83 | ADRB2 (0.67) | KDM4EADRB2ALDH1A1HTR7TP53 | |
| Water SCHEMBL27583143 | 0.82 | ADRB2 (0.65) | KDM4EADRB2ALDH1A1HTR7TP53 | |
| SCHEMBL27301114 | 0.80 | ADRB2 (0.63) | KDM4EADRB2ALDH1A1HTR7TP53 | |
| SCHEMBL10706756 | 0.75 | ADRB2 (0.65) | KDM4EADRB2ALDH1A1HTR7TP53 | |
| SCHEMBL4724735 | 0.75 | PDE5A (0.40) | KDM4EADRB2ALDH1A1USP2TP53 | |
| SCHEMBL28311408 | 0.74 | KDM4E (0.75) | KDM4EALDH1A1TDP1HTR7TP53 | |
| SCHEMBL7638760 | 0.74 | ADRB2 (0.63) | KDM4EADRB2ALDH1A1HTR7TP53 | |
| SCHEMBL34465293 | 0.74 | ADRB2 (0.63) | KDM4EADRB2ALDH1A1HTR7TP53 | |
| SCHEMBL27528318 | 0.73 | ADRB2 (0.54) | KDM4EADRB2ALDH1A1HTR7TP53 | |
| SCHEMBL10438816 | 0.73 | HTR7 (0.53) | KDM4EADRB2ALDH1A1USP2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999723-B2 | Pyrazole-containing macrophage migration inhibitory factor inhibitors | YALE UNIVERSITY (US) | 2024-06-04 | — | — | US | claimed |
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2023-02-23 | — | — | US | claimed |
| US-20210002264-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2021-01-07 | — | — | US | claimed |
| WO-2019178480-A1 | PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | YALE UNIVERSITY (US) | 2019-09-19 | — | — | WO | claimed |
| US-11999723-B2 | Pyrazole-containing macrophage migration inhibitory factor inhibitors | YALE UNIVERSITY (US) | 2024-06-04 | — | — | US | disclosed |
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2023-02-23 | — | — | US | disclosed |
| US-20210002264-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2021-01-07 | — | — | US | disclosed |
| WO-2019178480-A1 | PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | YALE UNIVERSITY (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999723-B2 | Pyrazole-containing macrophage migration inhibitory factor inhibitors | MIF, MMP12, CSF1R | KDM4E 1525/4885ADRB2 3915/4885ALDH1A1 2824/4885 |
| US-20210002264-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | MIF, MMP12, CSF1R | KDM4E 1211/4885ADRB2 3915/4885ALDH1A1 2891/4885 |
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | MIF, MMP12, CSF1R | KDM4E 1525/4885ADRB2 3915/4885ALDH1A1 2824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.