Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.57 |
| ▸ | HTR3B | O95264 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870704 | 0.88 | HTR3E (0.70) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL29998630 | 0.88 | HTR3E (0.70) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL24103508 | 0.78 | SIGMAR1 (0.64) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL1822749 | 0.78 | HTR3E (0.64) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL11771698 | 0.78 | HTR3E (0.58) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL18837373 | 0.77 | ADRB1 (0.57) | ADRB1AKR1C3ALDH1A1LMNAHPGD | |
| SCHEMBL21572670 | 0.77 | MAPT (0.63) | AKR1C3ALDH1A1LMNAHPGDHTT | |
| SCHEMBL22815633 | 0.77 | CHIA (0.58) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL2056127 | 0.77 | GAA (0.63) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL7266357 | 0.77 | CHIA (0.58) | HTR3EHTR3BADRB1HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178510-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-09-19 | — | — | WO | disclosed |