Sugi Predict

Sugi Predict / Compounds / SCHEMBL21361526

SCHEMBL21361526

SCHEMBL21361526

C=C1CN(S(=O)(=O)c2ccc(N(C)C)cc2)CCCN(CC2CCCCC2)CCCN(S(=O)(=O)N2CCN(c3cccc(Cl)c3)CC2)C1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ CD4 P01730 5/20 0.41
▸ SORT1 Q99523 1/20 0.41
▸ HTR1A P08908 2/20 0.40
▸ KCNH2 Q12809 1/20 0.40
▸ PTPN11 Q06124 1/20 0.39
▸ PKM P14618 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ OPRK1 P41145 2/20 0.38
▸ THRB P10828 1/20 0.37
▸ HTR7 P34969 1/20 0.37
▸ HTR6 P50406 1/20 0.37
▸ MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21361536 0.91 L3MBTL1 (0.42) ALDH1A1CD4SORT1OPRK1THRB
SCHEMBL21361451 0.91 CD4 (0.46) LMNAALDH1A1CD4SORT1HTR1A
SCHEMBL23102134 0.89 CD4 (0.40) LMNAALDH1A1CD4SORT1HTT
SCHEMBL21361525 0.88 CD4 (0.44) LMNAALDH1A1CD4SORT1OPRK1
SCHEMBL21361494 0.87 CD4 (0.46) LMNAALDH1A1CD4SORT1PKM
Hydrochloric Acid SCHEMBL21359286 0.86 CD4 (0.48) LMNAALDH1A1CD4SORT1PKM
SCHEMBL23102145 0.86 CD4 (0.42) LMNAALDH1A1CD4SORT1HTT
SCHEMBL21361532 0.84 CD4 (0.44) LMNAALDH1A1CD4SORT1HTT
SCHEMBL21361524 0.84 CD4 (0.44) LMNAALDH1A1CD4SORT1HTT
SCHEMBL21361406 0.84 CD4 (0.45) LMNAALDH1A1CD4SORT1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors KEZAR LIFE SCIENCES (US) 2023-02-14 — — US disclosed
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2022-12-22 — — US disclosed
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2021-03-18 — — US disclosed
WO-2019178510-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2019-09-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors SEC61B, SEC61A1, SEC61G LMNA 4550/4885ALDH1A1 4848/4885CD4 3678/4885
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G LMNA 4448/4885ALDH1A1 4834/4885CD4 3727/4885
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G LMNA 4555/4885ALDH1A1 4817/4885CD4 3471/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.