Sugi Predict

Sugi Predict / Compounds / SCHEMBL21361536

SCHEMBL21361536

SCHEMBL21361536

C=C1CN(S(=O)(=O)c2ccc(N(C)C)cc2)CCCN(CC2CCCCC2)CCCN(S(=O)(=O)N2CCN(c3ccc(Cl)cc3)CC2)C1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ HTR7 P34969 2/20 0.42
▸ HTR6 P50406 2/20 0.42
▸ LSS P48449 2/20 0.41
▸ CD4 P01730 5/20 0.41
▸ SORT1 Q99523 1/20 0.41
▸ HSD11B1 P28845 1/20 0.40
▸ OPRK1 P41145 1/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ THRB P10828 1/20 0.37
▸ CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21361451 0.92 CD4 (0.46) HTR7CD4SORT1MEN1KMT2A
SCHEMBL21361526 0.91 LMNA (0.41) HTR7HTR6CD4SORT1OPRK1
SCHEMBL21361494 0.89 CD4 (0.46) L3MBTL1CD4SORT1MEN1KMT2A
SCHEMBL21361528 0.89 TP53 (0.41) L3MBTL1CD4SORT1OPRK1MEN1
Hydrochloric Acid SCHEMBL21359286 0.88 CD4 (0.48) L3MBTL1CD4SORT1MEN1KMT2A
SCHEMBL21361525 0.88 CD4 (0.44) L3MBTL1CD4SORT1HSD11B1OPRK1
SCHEMBL21361501 0.87 CD4 (0.43) CD4SORT1MEN1KMT2AALDH1A1
SCHEMBL21361532 0.86 CD4 (0.44) L3MBTL1CD4SORT1MEN1KMT2A
SCHEMBL21361524 0.86 CD4 (0.44) L3MBTL1CD4SORT1MEN1KMT2A
SCHEMBL23102145 0.86 CD4 (0.42) L3MBTL1CD4SORT1OPRK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors KEZAR LIFE SCIENCES (US) 2023-02-14 — — US disclosed
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2022-12-22 — — US disclosed
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2021-03-18 — — US disclosed
WO-2019178510-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2019-09-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors SEC61B, SEC61A1, SEC61G L3MBTL1 4760/4885HTR7 4167/4885HTR6 3861/4885
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G L3MBTL1 4748/4885HTR7 4235/4885HTR6 3697/4885
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G L3MBTL1 4721/4885HTR7 4052/4885HTR6 3573/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.