Sugi Predict

Sugi Predict / Compounds / SCHEMBL21361554

SCHEMBL21361554

SCHEMBL21361554

O=S(=O)(NCCCN(CCCNS(=O)(=O)N1CCCCC1)Cc1ccccc1)N1CCCCC1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.46
▸ TSHR P16473 1/20 0.46
▸ MAPT P10636 1/20 0.44
▸ ALDH1A1 P00352 4/20 0.42
▸ TBXAS1 P24557 2/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ DPP7 Q9UHL4 1/20 0.41
▸ GAA P10253 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ TMEM97 Q5BJF2 1/20 0.40
▸ SIGMAR1 Q99720 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2452519 0.75 ALDH1A1 (0.61) HPGDTSHRMAPTALDH1A1KDM4E
SCHEMBL4119590 0.75 ALDH1A1 (0.64) TSHRALDH1A1KDM4EGAATMEM97
Hydrochloric Acid SCHEMBL7621278 0.73 ALDH1A1 (0.62) TSHRALDH1A1KDM4EGAATMEM97
SCHEMBL21361556 0.71 DPP7 (0.38) DPP7HTT
SCHEMBL7617426 0.69 TDP1 (0.52) ALDH1A1KDM4ETMEM97SIGMAR1TDP1
SCHEMBL7203881 0.69 CA12 (0.63) HPGDMAPTALDH1A1GAAHTT
SCHEMBL23102120 0.68 FABP6 (0.41) ALDH1A1
SCHEMBL966736 0.67 HPGD (0.54) HPGDTSHRALDH1A1POLBDPP7
SCHEMBL21359124 0.67 CA1 (0.41) TSHRALDH1A1TBXAS1POLBGAA
SCHEMBL21361488 0.67 ALDH1A1 (0.49) HPGDTSHRMAPTALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors KEZAR LIFE SCIENCES (US) 2023-02-14 — — US disclosed
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2022-12-22 — — US disclosed
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2021-03-18 — — US disclosed
WO-2019178510-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2019-09-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors SEC61B, SEC61A1, SEC61G HPGD 1016/4885TSHR 727/4885MAPT 3927/4885
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G HPGD 723/4885TSHR 976/4885MAPT 4037/4885
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G HPGD 798/4885TSHR 616/4885MAPT 4113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.