Sugi Predict

Sugi Predict / Compounds / SCHEMBL21361592

SCHEMBL21361592

SCHEMBL21361592

CN(C)c1ccc(S(=O)(=O)N2CCCCN(S(=O)(=O)N3CCC(c4ccccc4)CC3)CCCN(CC3CCCCC3)CCC2)cc1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 6/20 0.48
▸ HTT P42858 2/20 0.48
▸ ALDH1A1 P00352 4/20 0.45
▸ USP5 P45974 3/20 0.44
▸ TSHR P16473 4/20 0.44
▸ SMN1; SMN2 Q16637 4/20 0.44
▸ CCR5 P51681 1/20 0.44
▸ STAT3 P40763 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ HDAC6 Q9UBN7 1/20 0.44
▸ MEN1 O00255 3/20 0.43
▸ KMT2A Q03164 3/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ APOBEC3A P31941 1/20 0.42
▸ APOBEC3G Q9HC16 1/20 0.42
▸ GAA P10253 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.41
▸ CCR2 P41597 1/20 0.40
▸ HRH3 Q9Y5N1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21359148 0.99 LMNA (0.47) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21361462 0.99 LMNA (0.46) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21361543 0.93 CCR5 (0.41) LMNAHTTALDH1A1USP5TSHR
SCHEMBL23102100 0.93 CCR5 (0.41) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21361530 0.92 NPSR1 (0.46) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21358919 0.92 LMNA (0.41) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21358939 0.92 NPSR1 (0.46) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21361625 0.92 NPSR1 (0.46) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21359059 0.92 LMNA (0.44) LMNAHTTALDH1A1USP5TSHR
SCHEMBL21361509 0.91 CD4 (0.46) LMNAHTTALDH1A1USP5TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors KEZAR LIFE SCIENCES (US) 2023-02-14 — — US disclosed
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2022-12-22 — — US disclosed
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2021-03-18 — — US disclosed
WO-2019178510-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2019-09-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors SEC61B, SEC61A1, SEC61G LMNA 4550/4885HTT 2931/4885ALDH1A1 4848/4885
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G LMNA 4448/4885HTT 3046/4885ALDH1A1 4834/4885
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G LMNA 4555/4885HTT 3038/4885ALDH1A1 4817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.