Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26862272 | 0.85 | LMNA (0.60) | LMNAHTR2BTHRBUSP2EPHX1 | |
| SCHEMBL13810503 | 0.84 | LMNA (0.61) | LMNAHTR2BTHRBUSP2TP53 | |
| SCHEMBL14895871 | 0.82 | LMNA (0.57) | LMNAHTR2BTHRBUSP2EPHX1 | |
| SCHEMBL4457699 | 0.82 | RAB9A (0.59) | LMNAHTR2BTHRBUSP2EPHX1 | |
| SCHEMBL21361620 | 0.81 | LMNA (0.57) | LMNAHTR2BTHRBUSP2TP53 | |
| SCHEMBL1128181 | 0.80 | RAB9A (0.62) | LMNAHTR2BTHRBUSP2EPHX1 | |
| SCHEMBL5014849 | 0.80 | LMNA (0.70) | LMNAHTR2BTHRBUSP2EPHX1 | |
| SCHEMBL3120801 | 0.79 | LMNA (0.55) | LMNAHTR2BTHRBUSP2EPHX1 | |
| SCHEMBL5014847 | 0.79 | LMNA (0.73) | LMNAHTR2BTHRBUSP2EPHX1 | |
| SCHEMBL27969428 | 0.79 | BCHE (0.59) | LMNAHTR2BUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178510-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-09-19 | — | — | WO | disclosed |