Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21361639 | 0.92 | HSD11B1 (0.41) | HSD11B1LMNAGAASMN1; SMN2 | |
| SCHEMBL23102282 | 0.92 | HSD11B1 (0.41) | HSD11B1LMNAGAASMN1; SMN2 | |
| SCHEMBL21361487 | 0.89 | LMNA (0.43) | LMNAGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21361409 | 0.82 | SMN1; SMN2 (0.45) | HSD11B1LMNAGAASMN1; SMN2OPRK1 | |
| SCHEMBL23102160 | 0.81 | CYP3A4 (0.36) | LMNAGAASMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL21361616 | 0.81 | ALDH1A1 (0.41) | LMNAGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21361498 | 0.80 | LMNA (0.43) | HSD11B1LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21361542 | 0.79 | SMN1; SMN2 (0.43) | LMNAGAASMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL21361503 | 0.79 | ALDH1A1 (0.45) | HSD11B1LMNAALDH1A1MAPTCYP19A1 | |
| SCHEMBL21361500 | 0.78 | HTR1A (0.45) | LMNAGAASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178510-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-09-19 | — | — | WO | disclosed |