Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.64 |
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25906326 | 0.87 | HSP90AA1 (0.55) | HSP90AA1BACE1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL6878813 | 0.86 | BACE1 (0.56) | HSP90AA1BACE1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL4239928 | 0.83 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1GABRA1GABRB2ALDH1A1 | |
| SCHEMBL25906339 | 0.82 | HSP90AA1 (0.60) | HSP90AA1BACE1HSP90AB1ALDH1A1TRPA1 | |
| SCHEMBL22312941 | 0.82 | HSP90AA1 (0.50) | HSP90AA1BACE1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL22888772 | 0.82 | TSHR (0.56) | HSP90AA1BACE1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL4065970 | 0.81 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1TRPA1LMNACHRM1 | |
| SCHEMBL4064793 | 0.81 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1GABRA1ALOX5TRPA1 | |
| SCHEMBL4383317 | 0.80 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALOX5ALDH1A1 | |
| SCHEMBL4063286 | 0.80 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1GABRA1GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
| US-20210009621-A1 | AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-01-14 | — | — | US | disclosed |
| WO-2019178119-A1 | AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009621-A1 | AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE | AAAS, PROC, AADAC | HSP90AA1 1344/4885BACE1 3953/4885HSP90AB1 1341/4885 |
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | AAAS, PROC, AADAC | HSP90AA1 1344/4885BACE1 3953/4885HSP90AB1 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.