SCHEMBL4064793

SCHEMBL4064793

CC(C)c1cc(-c2ccc(Cl)cc2)c(O)cc1O

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 9/20 0.54
HSP90AB1 P08238 6/20 0.54
LMNA P02545 3/20 0.47
GABRA1 P14867 1/20 0.44
GABRB1 P18505 1/20 0.44
ALOX5 P09917 1/20 0.42
TRPA1 O75762 1/20 0.41
CHRM1 P11229 1/20 0.41
SLC6A2 P23975 1/20 0.41
ADRA1A P35348 1/20 0.41
HTR2B P41595 1/20 0.41
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TRPV1 Q8NER1 2/20 0.40
GCGR P47871 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25906339 0.83 HSP90AA1 (0.60) HSP90AA1HSP90AB1LMNATRPA1CHRM1
SCHEMBL4065970 0.81 HSP90AA1 (0.54) HSP90AA1HSP90AB1LMNATRPA1CHRM1
SCHEMBL21363250 0.81 HSP90AA1 (0.64) HSP90AA1HSP90AB1LMNAGABRA1ALOX5
SCHEMBL4241557 0.79 APP (0.50) HSP90AA1HSP90AB1LMNAALOX5TRPA1
SCHEMBL4060757 0.79 HSP90AA1 (0.43) HSP90AA1HSP90AB1LMNATRPA1CHRM1
SCHEMBL9812827 0.77 ALOX5 (0.58) LMNAALOX5MEN1MAPTMAPK1
SCHEMBL28702727 0.77 MAPK14 (0.46) HSP90AA1HSP90AB1
SCHEMBL19996996 0.76 LMNA (0.50) HSP90AA1HSP90AB1LMNAGABRA1GABRB1
SCHEMBL4069702 0.76 HSP90AA1 (0.44) HSP90AA1HSP90AB1LMNATRPA1CHRM1
SCHEMBL13848090 0.75 HSP90AA1 (0.46) HSP90AA1HSP90AB1LMNATRPA1CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009066060-A2 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE TOPOTARGET A/S (DK) 2009-05-28 WO disclosed
WO-2009066060-A2 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE TOPOTARGET A/S (DK) 2009-05-28 WO disclosed