SCHEMBL4063286

SCHEMBL4063286

CC(C)c1cc(-c2cccc(N)c2)c(O)cc1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.49
MAOA P21397 1/20 0.41
MCL1 Q07820 1/20 0.41
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
MAP4K4 O95819 1/20 0.40
HSP90AB1 P08238 4/20 0.40
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 2/20 0.38
SLC6A2 P23975 2/20 0.38
HTR2B P41595 2/20 0.38
FAAH O00519 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
GABRA1 P14867 1/20 0.38
HPGD P15428 1/20 0.38
TSHR P16473 1/20 0.38
GABRB1 P18505 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4239928 0.83 HSP90AA1 (0.51) HSP90AA1HSP90AB1CA1CA2ALDH1A1
SCHEMBL21363250 0.80 HSP90AA1 (0.64) HSP90AA1HSP90AB1ALDH1A1LMNASLC6A2
SCHEMBL30777025 0.77 MAOA (0.50) MAOAMAP4K4CA1CA2ALDH1A1
SCHEMBL8359609 0.77 MAOA (0.50) MAOAMAP4K4CA1CA2ALDH1A1
SCHEMBL28628075 0.76 MAP4K4 (0.46) MAOAMAP4K4CA1CA2ALDH1A1
SCHEMBL4241557 0.75 APP (0.50) HSP90AA1HSP90AB1LMNASLC6A2HTR2B
SCHEMBL6575802 0.74 MAOA (0.50) MAOAMCL1CNR1CNR2MAP4K4
SCHEMBL3784572 0.74 MCL1 (0.51) MAOAMCL1CNR1CNR2MAP4K4
SCHEMBL21409737 0.73 MAOA (0.41) MAOAMAP4K4ALDH1A1LMNACYP3A4
SCHEMBL4383317 0.73 HSP90AA1 (0.52) HSP90AA1HSP90AB1ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009066060-A2 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE TOPOTARGET A/S (DK) 2009-05-28 WO disclosed
WO-2009066060-A2 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE TOPOTARGET A/S (DK) 2009-05-28 WO disclosed