SCHEMBL21363801

SCHEMBL21363801

CC(C)(C)c1cc2c(cc1O)OCO2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 7/20 0.56
ALDH1A1 P00352 5/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
CYP1A2 P05177 2/20 0.56
KDM4E B2RXH2 1/20 0.56
MAPT P10636 1/20 0.56
ATP2A2 P16615 1/20 0.56
ATP2A3 Q93084 1/20 0.56
CYP3A4 P08684 4/20 0.42
TP53 P04637 3/20 0.42
LMNA P02545 2/20 0.42
HPGD P15428 1/20 0.42
CYP2C9 P11712 3/20 0.42
TYR P14679 2/20 0.42
NR1I2 O75469 1/20 0.42
MIF P14174 1/20 0.42
HTT P42858 1/20 0.42
NFE2L2 Q16236 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TSHR P16473 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6364660 0.84 CYP3A4 (0.39) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL14284004 0.80 PDE4D (0.39) ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E
SCHEMBL14308419 0.77 ESR1 (0.42) ALOX15ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL18308983 0.77 ALOX5 (0.38) ALDH1A1SMN1; SMN2CYP1A2KDM4EMAPT
SCHEMBL2268770 0.77 CYP3A4 (0.56) ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT
SCHEMBL4995839 0.75 MAPT (0.43) ALOX15ALDH1A1SMN1; SMN2KDM4EMAPT
SCHEMBL4135020 0.75 CYP3A4 (0.33) ALDH1A1SMN1; SMN2CYP3A4LMNAHPGD
SCHEMBL12203329 0.75 PTGS2 (0.37) ALDH1A1CYP1A2MAPTCYP3A4LMNA
SCHEMBL8248216 0.75 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2CYP1A2KDM4EMAPT
SCHEMBL7440407 0.75 CYP3A4 (0.33) ALDH1A1MAPTCYP3A4LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019175712-A1 NEW USES FOR CATECHOL MOLECULES AS INHIBITORS TO GLUTATHIONE S-TRANSFERASE METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed
WO-2019175713-A1 NEW CATECHOL MOLECULES AND THEIR USE AS INHIBITORS TO P450 RELATED METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed