SCHEMBL7440407

SCHEMBL7440407

CC(C)(C)c1cc2c(cc1S)OCO2

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.33
PGR P06401 1/20 0.33
AR P10275 1/20 0.33
GABRA1 P14867 1/20 0.33
MAOA P21397 1/20 0.33
SLC6A2 P23975 1/20 0.33
PDE4A P27815 1/20 0.33
KDR P35968 1/20 0.33
GABRB2 P47870 1/20 0.33
SLC6A3 Q01959 1/20 0.33
ATM Q13315 1/20 0.32
ABCG2 Q9UNQ0 1/20 0.31
MAPK9 P45984 2/20 0.31
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31
CHRNA7 P36544 1/20 0.31
HTR1A P08908 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6364660 0.84 CYP3A4 (0.39) CYP3A4PGRARGABRA1MAOA
SCHEMBL18308983 0.77 ALOX5 (0.38) CYP3A4PGRARGABRA1MAOA
SCHEMBL8248216 0.75 ALDH1A1 (0.40) CYP3A4PGRARGABRA1MAOA
SCHEMBL21363801 0.75 ALOX15 (0.56) CYP3A4PGRARGABRA1MAOA
SCHEMBL4135020 0.75 CYP3A4 (0.33) CYP3A4PGRARGABRA1MAOA
SCHEMBL4995839 0.75 MAPT (0.43) CYP3A4PGRARGABRA1MAOA
SCHEMBL12203329 0.75 PTGS2 (0.37) CYP3A4PGRARGABRA1MAOA
SCHEMBL24008355 0.73 ALDH1A1 (0.40) CYP3A4LMNAHPGDALDH1A1ALOX5
SCHEMBL23480218 0.72 CYP3A4 (0.36) CYP3A4PGRARGABRA1MAOA
SCHEMBL18103322 0.71 CYP3A4 (0.37) CYP3A4ATMABCG2MAPK9LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5936128-A BENZENETHIOL COMPOUNDS AS INTERMEDIATES; BACTERICIDES, VIRICIDES; HIV WARNER-LAMBERT COMPANY (US) 1999-08-10 US claimed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US claimed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP claimed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP claimed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO claimed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO claimed