Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20055066 | 0.84 | LMNA (0.33) | LMNAMAPTNPC1RAB9ATRPA1 | |
| SCHEMBL22791425 | 0.76 | GAA (0.37) | MAPTNPC1RAB9AGAACYP2C9 | |
| SCHEMBL20860302 | 0.76 | ADRA2A (0.32) | — | |
| SCHEMBL20860303 | 0.73 | SIGMAR1 (0.37) | LMNAMAPTPTGS1GAACYP2C9 | |
| SCHEMBL26345706 | 0.72 | LMNA (0.39) | LMNAMAPTNPC1RAB9ATRPA1 | |
| SCHEMBL20987638 | 0.72 | LMNA (0.54) | LMNAMAPTTRPA1PTGS1CACNA1C | |
| SCHEMBL19334606 | 0.71 | LMNA (0.38) | LMNAMAPTNPC1RAB9ATRPA1 | |
| SCHEMBL22537648 | 0.71 | LMNA (0.38) | LMNAMAPTNPC1RAB9ATRPA1 | |
| SCHEMBL14044154 | 0.71 | LMNA (0.38) | LMNAMAPTNPC1RAB9ATRPA1 | |
| SCHEMBL25931172 | 0.71 | LMNA (0.52) | LMNAMAPTTRPA1PTGS1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230277-B1 | SUBSTITUTED HETEROCYCLES AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD (CA) | 2019-09-18 | — | — | EP | disclosed |