Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18290405 | 0.81 | TRPA1 (0.50) | TRPA1CARM1PTGESAAK1 | |
| SCHEMBL21377327 | 0.81 | TRPA1 (0.50) | TRPA1CARM1PRMT6PTGESHDAC1 | |
| SCHEMBL21377329 | 0.80 | NTRK1 (0.47) | CARM1PRMT6AAK1HDAC8 | |
| SCHEMBL18236621 | 0.75 | TRPA1 (0.56) | TRPA1 | |
| SCHEMBL18224016 | 0.74 | TRPA1 (0.54) | TRPA1 | |
| SCHEMBL18223953 | 0.73 | LOXL2 (0.40) | TRPA1AAK1CYP2D6HDAC1 | |
| SCHEMBL21377114 | 0.71 | PTGES (0.52) | TRPA1CARM1PTGES | |
| SCHEMBL21377339 | 0.70 | TRPA1 (0.51) | TRPA1PTGESHDAC8HDAC1 | |
| SCHEMBL14931534 | 0.69 | SMN1; SMN2 (0.66) | CYP1A2CYP2D6MAPTTSHRSMN1; SMN2 | |
| SCHEMBL21377444 | 0.68 | PTGES (0.43) | TRPA1CARM1PTGESCYP1A2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101015-B1 | HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME | EA PHARMA CO LTD (JP) | 2019-09-18 | — | — | EP | disclosed |