SCHEMBL2138333

SCHEMBL2138333

COC(=O)c1cc2c(Cl)c(OC)ccc2s1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNC P24863 1/20 0.50
CDK8 P49336 1/20 0.50
HDAC3 O15379 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC11 Q96DB2 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
HDAC9 Q9UKV0 1/20 0.50
HDAC5 Q9UQL6 1/20 0.50
MAPT P10636 3/20 0.47
KDM4E B2RXH2 1/20 0.47
SLC9A1 P19634 2/20 0.43
NOTUM Q6P988 1/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
CLK1 P49759 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6331785 0.84 CCNC (0.49) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL9431710 0.84 HDAC1 (0.52) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL829477 0.83 CCNC (0.48) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL9432038 0.82 CCNC (0.47) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL24175593 0.81 CCNC (0.49) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL828798 0.80 HDAC3 (0.76) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL2626936 0.79 CCNC (0.45) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL830367 0.78 ALDH1A1 (0.51) CCNCCDK8HDAC3HDAC4HDAC1
SCHEMBL17842695 0.78 MAPT (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL24858604 0.78 CCNC (0.46) CCNCCDK8HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2403843-B1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES LIFE TECHNOLOGIES CORP (US) 2018-11-07 EP disclosed
US-9856508-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2018-01-02 US disclosed
US-9856508-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2018-01-02 US disclosed
US-20170137862-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation 2017-05-18 US disclosed
US-20170137862-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation 2017-05-18 US disclosed
US-20170137862-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation 2017-05-18 US disclosed
US-9518285-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2016-12-13 US disclosed
US-9518285-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2016-12-13 US disclosed
US-9518285-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2016-12-13 US disclosed
US-20150284766-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation 2015-10-08 US disclosed
US-20150284766-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation 2015-10-08 US disclosed
US-20150284766-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation 2015-10-08 US disclosed
US-9067910-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2015-06-30 US disclosed
US-9067910-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2015-06-30 US disclosed
US-9067910-B2 Chemiluminescent compositions, methods, assays and kits for oxidative enzymes Life Technologies Corporation (US) 2015-06-30 US disclosed
US-20120100566-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation (US) 2012-04-26 US disclosed
US-20120100566-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation (US) 2012-04-26 US disclosed
US-20120100566-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation (US) 2012-04-26 US disclosed
WO-2010101839-A2 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES Life Technologies Corporation (US) 2010-09-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284766-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES AOX1, CAT, LPO CCNC 3142/4885CDK8 2788/4885HDAC3 2759/4885
US-20120100566-A1 CHEMILUMINESCENT COMPOSITIONS, METHODS, ASSAYS AND KITS FOR OXIDATIVE ENZYMES CBR1, AOX1, POR CCNC 3674/4885CDK8 2759/4885HDAC3 2815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.