Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29576932 | 0.84 | OPRM1 (0.60) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL6290697 | 0.83 | OPRK1 (0.71) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL6290696 | 0.83 | OPRK1 (0.71) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL6290699 | 0.83 | OPRK1 (0.71) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL21383314 | 0.81 | OPRD1 (0.53) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL21383313 | 0.81 | OPRD1 (0.53) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL11086789 | 0.79 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL11248997 | 0.74 | SLC6A4 (0.79) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL11251511 | 0.74 | SLC6A4 (0.79) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 | |
| SCHEMBL11249000 | 0.74 | SLC6A4 (0.79) | SLC6A4SLC6A2SLC6A3OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768679-B1 | BIASED POTENT OPIOID-LIKE AGONISTS AS IMPROVED MEDICATIONS TO TREAT CHRONIC AND ACUTE PAIN AND METHODS OF USING THE SAME | US HEALTH (US) | 2024-06-26 | — | — | EP | disclosed |
| US-11352365-B2 | Biased potent opioid-like agonists as improved medications to treat chronic and acute pain and methods of using the same | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210024532-A1 | BIASED POTENT OPIOID-LIKE AGONISTS AS IMPROVED MEDICATIONS TO TREAT CHRONIC AND ACUTE PAIN AND METHODS OF USING THE SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-01-28 | — | — | US | disclosed |
| EP-3768679-A1 | BIASED POTENT OPIOID-LIKE AGONISTS AS IMPROVED MEDICATIONS TO TREAT CHRONIC AND ACUTE PAIN AND METHODS OF USING THE SAME | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019182950-A1 | BIASED POTENT OPIOID-LIKE AGONISTS AS IMPROVED MEDICATIONS TO TREAT CHRONIC AND ACUTE PAIN AND METHODS OF USING THE SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024532-A1 | BIASED POTENT OPIOID-LIKE AGONISTS AS IMPROVED MEDICATIONS TO TREAT CHRONIC AND ACUTE PAIN AND METHODS OF USING THE SAME | OPRL1, OPRK1, OPRM1 | SLC6A4 523/4885SLC6A2 731/4885SLC6A3 369/4885 |
| US-11352365-B2 | Biased potent opioid-like agonists as improved medications to treat chronic and acute pain and methods of using the same | OPRL1, OPRK1, OPRM1 | SLC6A4 523/4885SLC6A2 731/4885SLC6A3 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.