Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL9441873 | 0.95 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL6306849 | 0.82 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL28835057 | 0.82 | — | — | |
| Piperidine SCHEMBL8528732 | 0.79 | ALDH1A1 (0.69) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL27278836 | 0.79 | ALDH1A1 (0.69) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL2373879 | 0.78 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL577429 | 0.78 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL22003 | 0.78 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL3999265 | 0.78 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL5033222 | 0.78 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235604-B2 | Polyamide- and polyolefin-based fire-retarded compositions | ATOFINA (FR) | 2007-06-26 | — | — | US | claimed |
| EP-1375594-B1 | Flame retardant compositions based on polyamide and polyolefine | ARKEMA (FR) | 2005-12-14 | — | — | EP | claimed |
| CN-1215123-C | Polyamide and polyolefine refractory composition | ATOFINA (FR) | 2005-08-17 | — | — | CN | claimed |
| US-20040054054-A1 | Polyamide-and polyolefin-based fire-retarded compositions | ANTOFINA (FR) | 2004-03-18 | — | — | US | claimed |
| CN-1468906-A | Polyamide and polyolefine refractory composition | ���з��ɹ�˾ | 2004-01-21 | — | — | CN | claimed |
| CN-1100439-A | Flame-retardant compositions for mixtures of thermoplastic resins containing a zeolite and mixtures of thermoplastic resins including the said compositions | ATOCHEM ELF SA (FR) | 1995-03-22 | — | — | CN | claimed |
| EP-0286478-B1 | PHOSPHOROUS-ACID SALTS, THEIR COMMPOSITIONS AND THEIR USE AS FIRE-PROOFING AGENTS | ELF ATOCHEM S.A. (FR) | 1993-03-10 | — | — | EP | claimed |
| US-12018140-B2 | Flexible fire-retardant thermoplastic compositions having high thermomechanical strength, in particular for electric cables | SK GEO CENTRIC CO., LTD. (KR) | 2024-06-25 | — | — | US | disclosed |
| CN-105593340-B | Flexible flameproof thermoplastic composition with high thermomechanical strength, in particular for electric cables | 阿肯马法国公司 | 2020-11-03 | — | — | CN | disclosed |
| US-20160185942-A1 | FLEXIBLE FIRE-RETARDANT THERMOPLASTIC COMPOSITIONS HAVING HIGH THERMOMECHANICAL STRENGTH, IN PARTICULAR FOR ELECTRIC CABLES | ARKEMA FRANCE (FR) | 2016-06-30 | — | — | US | disclosed |
| CN-105593340-A | Flexible flameproof thermoplastic composition with high thermomechanical strength, in particular for electric cables | ARKEMA FRANCE | 2016-05-18 | — | — | CN | disclosed |
| US-7897673-B2 | Flexible high thermomechanical stress-resistant and fireproof halogen-free thermoplastic compositions | ARKEMA FRANCE (FR) | 2011-03-01 | — | — | US | disclosed |
| US-20090253836-A1 | FLEXIBLE HIGH THERMOMECHANICAL STRESS-RESISTANT AND FIREPROOF HALOGEN-FREE THERMOPLASTIC COMPOSITIONS | ARKEMA FRANCE (FR) | 2009-10-08 | — | — | US | disclosed |
| US-7235604-B2 | Polyamide- and polyolefin-based fire-retarded compositions | ATOFINA (FR) | 2007-06-26 | — | — | US | disclosed |
| CN-1215123-C | Polyamide and polyolefine refractory composition | ATOFINA (FR) | 2005-08-17 | — | — | CN | disclosed |
| US-20040054054-A1 | Polyamide-and polyolefin-based fire-retarded compositions | ANTOFINA (FR) | 2004-03-18 | — | — | US | disclosed |
| CN-1468906-A | Polyamide and polyolefine refractory composition | ���з��ɹ�˾ | 2004-01-21 | — | — | CN | disclosed |
| CN-1100439-A | Flame-retardant compositions for mixtures of thermoplastic resins containing a zeolite and mixtures of thermoplastic resins including the said compositions | ATOCHEM ELF SA (FR) | 1995-03-22 | — | — | CN | disclosed |
| CN-1100438-A | Zeolite containing composition for fireproof of synthetic resin and synthetic resin containing same | ATOCHEM ELF SA (FR) | 1995-03-22 | — | — | CN | disclosed |
| US-4879327-A | PLASTICS | ATOCHEM (FR) | 1989-11-07 | — | — | US | disclosed |