SCHEMBL21384577

SCHEMBL21384577

COC(=O)c1cc(Br)c(F)cc1NS(=O)(=O)C1CC1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MRGPRX1 Q96LB2 10/20 0.42
TSPO P30536 2/20 0.40
HSD17B10 Q99714 2/20 0.40
KDM4E B2RXH2 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
SIRT6 Q8N6T7 1/20 0.39
YAP1 P46937 1/20 0.39
ALDH1A1 P00352 2/20 0.38
HPGD P15428 2/20 0.38
TSHR P16473 1/20 0.38
HRH1 P35367 1/20 0.38
SOS1 Q07889 1/20 0.38
ACLY P53396 1/20 0.38
TLR4 O00206 1/20 0.36
BRAF P15056 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21384569 0.85 ACLY (0.48) MRGPRX1TSPOKDM4ESIRT6HRH1
SCHEMBL21384566 0.85 MRGPRX1 (0.42) MRGPRX1TSPOHSD17B10KDM4ESMN1; SMN2
SCHEMBL13337363 0.79 ALDH1A1 (0.49) MRGPRX1TSPOHSD17B10KDM4ESMN1; SMN2
SCHEMBL21384614 0.75 MRGPRX1 (0.57) MRGPRX1TSPOYAP1ACLYTLR4
SCHEMBL15847427 0.74 ACLY (0.54) MRGPRX1TSPOHSD17B10KDM4ESMN1; SMN2
SCHEMBL31394743 0.74 SOS1 (0.51) HSD17B10KDM4ESIRT6ALDH1A1HPGD
SCHEMBL23301861 0.74 KDM4E (0.44) HSD17B10KDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL21381359 0.73 MRGPRX1 (0.43) MRGPRX1TSPOHSD17B10ALDH1A1HPGD
SCHEMBL365953 0.72 SOS1 (0.50) HSD17B10KDM4ESIRT6ALDH1A1HPGD
SCHEMBL31079873 0.72 SOS1 (0.50) HSD17B10KDM4ESIRT6ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019179436-A1 ACID AMIDE COMPOUND AND USE THEREOF IN TREATMENT OF CANCERS 成都海创药业有限公司 2019-09-26 WO disclosed
WO-2019179436-A1 ACID AMIDE COMPOUND AND USE THEREOF IN TREATMENT OF CANCERS 成都海创药业有限公司 2019-09-26 WO disclosed