SCHEMBL21385069

SCHEMBL21385069

Brc1ccc2c(c1)-c1cccc3ccnc(c13)S2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.37
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
HTT P42858 1/20 0.35
TYMS P04818 1/20 0.33
ALDH1A1 P00352 3/20 0.33
HSD17B10 Q99714 3/20 0.33
TSHR P16473 2/20 0.33
MAPK1 P28482 2/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
HIF1A Q16665 1/20 0.33
HDAC7 Q8WUI4 2/20 0.32
HDAC8 Q9BY41 2/20 0.32
HDAC4 P56524 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
PLAU P00749 2/20 0.32
PLG P00747 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21385100 0.89 MAOA (0.34) MAOA
SCHEMBL21382715 0.89 MAOA (0.37) MAOACYP1A2CYP2C19HTTTYMS
SCHEMBL30496684 0.79 TYMS (0.50) CYP1A2TYMSALDH1A1HSD17B10TSHR
SCHEMBL17283583 0.79 TYMS (0.50) CYP1A2TYMSALDH1A1HSD17B10TSHR
SCHEMBL21385118 0.74 LPL (0.37) MAOA
SCHEMBL21385095 0.73 IDO1 (0.34) MAOAHTTALDH1A1HSD17B10TSHR
SCHEMBL21385139 0.72 RECQL (0.36) CYP1A2CYP2C19HTTTP53HDAC7
SCHEMBL23587858 0.72
SCHEMBL21382879 0.70 ALDH1A1 (0.38) MAOATYMSALDH1A1HSD17B10TP53
SCHEMBL21385274 0.69 MAOA (0.43) MAOACYP1A2CYP2C19HTTTYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019182360-A1 COMPOUND, ORGANIC LIGHT-EMITTING DEVICE AND DISPLAY DEVICE 에스케이머티리얼즈 주식회사 2019-09-26 WO disclosed